Mechanism in biology

William Bechtel, Discovering Cell Mechanisms: The Creation of Modern Cell Biology (2006)

William Bechtel, “Mechanism and Biological Explanation,” Philosophy of Science (2011)

William Bechtel, “Biological Mechanisms: organized to maintain autonomy,” in Systems Biology: Philosophical Foundations (2007)

Carl Craver and James Tabery, “Mechanisms in Science,” Stanford Encyclopedia of Philosophy (2015)

Carl F. Craver and Lindley Darden, In Search of Mechanisms: Discoveries Across the Life Sciences (2013)

Margaret Gardel, “Moving beyond molecular mechanisms,” Journal of Cell Biology (2015)

Daniel J. Nicholson, “The concept of mechanism in biology,” Studies in History and Philosophy of Biological and Biomedical Sciences (2012)

Rob Phillips, “Musings on mechanism: quest for a quark theory of proteins?” Journal of the Federation of American Societies for Experimental Biology (2017)

James Tabery, Monika Piotrowska, and Lindley Daren, “Molecular Biology,” Stanford Encyclopedia of Philosophy (2015)

Quite an everyday occurrence

from Huygens and Barrow, Newton and Hooke, Vladimir Arnold, translated by Eric J. F. Primrose (1989):

Hooke was a poor man and began work as an assistant to Boyle (who is now well known thanks to the Boyle-Mariotte law discovered by Hooke). Subsequently Hooke began working in the recently established Royal Society (that is, the English Academy of Sciences) as Curator. The duties of the Curator of the Royal Society were very onerous. According to his contract, at every session of the Society (and they occurred every week except for the summer vacation) he had to demonstrate three or four experiments proving the new laws of nature.

Hooke held the post of Curator for forty years, and all that time he carried out his duties thoroughly. Of course, there was no condition in the contract that all the laws to be demonstrated had to be devised by him. He was allowed to read books, correspond with other scientists, and to be interested in their discoveries. He was only required to verify whether their statements were true and to convince the Royal Society that some law was reliably established. For this it was necessary to prove this law experimentally and demonstrate the appropriate experiment. This was Hooke’s official activity.


At that time it was easy to carry out fundamental discoveries, and large numbers of them were carried out. Huygens, for example, improved the telescope, looked at Saturn and discovered its ring, and Hooke discovered the red spot on Jupiter. At that time discoveries were not unusual events, they were not registered, not patented, as they are now, they were quite an everyday occurrence. (This was the case not only in the natural sciences. Mathematical discoveries at that time also poured forth as if from a horn of plenty.)

But Hooke never had enough time to dwell on any of his discoveries and develop it in detail, since in the following week he needed to demonstrate new laws. So in the whole manifold of Hooke’s achievements his discoveries appeared somewhat incomplete, and sometimes when he was in a hurry he made assertions that he could not justify accurately and with mathematical rigour.


Holding the chair at Cambridge, Newton earned considerably more (200 pounds a year), and the farm that he had inherited, which he leased out and where the famous apple tree grew, gave him roughly the same income. Despite the fact that Newton was quite well off, he did not want to spend any money on the publication of the book, so he sent the Principia to the Royal Society, which decided to publish the book at its own expense. But the Society had no money, so the manuscript lay there until Halley (who was the son of a rich soap manufacturer) published it on his own account. Halley took on himself all the trouble of publishing the book, and even read the proofs himself. Newton, in correspondence at this time, called it “Your book”…